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'EEG abnormalities' may represent a confounding factor in celiac disease: A 4-year follow-up family report

机译：“ EEG异常”可能代表乳糜泻的混杂因素：一项为期4年的随访家庭报告

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Objective: The occurrence of celiac disease (CD), electroencephalographic (EEG) abnormalities (with "subtle" seizures or even without any clinical seizures), and neurological disorders has been reported since the 1980s, though there has been no definitive consensus about the possible causal relationship. This topic is further complicated by the occurrence in infancy of 'clinical-EEG pictures' called 'benign epilepsy of infancy'. Methods and results: Here, we report a 4-year follow-up on two siblings with newly diagnosed biopsy-proven celiac disease showing EEG abnormalities not responsive to a gluten-free diet. Conclusions: This family report indicates that in patients with neurologically asymptomatic CD and EEG abnormalities, it is advisable to make a differential diagnosis between EEG abnormalities associated with CD and an incidental association with cortical hyperexcitability, with "subtle" seizures or even without any clinical seizures. Practice implications: A long follow-up may sometimes be required, as it was in the family described here, to clarify the etiopathogenetic and therapeutic relationships between clinical and EEG features in CD. © 2014.
机译：目的：自1980年代以来，已经报道了发生腹腔疾病（CD），脑电图（EEG）异常（伴有“轻微”癫痫发作，甚至没有任何临床癫痫发作）和神经系统疾病的情况，尽管尚未就是否存在这种可能性达成明确共识因果关系。婴儿期出现的“临床脑电图图片”（称为“婴儿期良性癫痫”）使这一话题更加复杂。方法和结果：在这里，我们报告了两个兄弟姐妹对新诊断的经活检证实的乳糜泻进行了为期4年的随访，显示出对无麸质饮食无反应的脑电图异常。结论：该家族报告表明，对于无神经系统症状的CD和EEG异常的患者，建议对与CD相关的EEG异常与皮质过度兴奋性，“轻微”发作甚至无任何临床发作的偶然关联进行鉴别诊断。 。实践意义：有时可能需要长时间的随访，以阐明CD的临床特征和脑电图特征之间的病因和治疗关系，就像这里描述的家族一样。 ©2014。

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